Derivation of a high-resolution CT-based, semi-automated radiographic score in tuberculosis and its relationship to bacillary load and antitubercular therapy
Extract
Efforts to curb the tuberculosis (TB) pandemic remain hindered by a lack of objective measures to quantify disease severity and track treatment success that are valid in both HIV-1-infected and -uninfected TB patients. Ralph et al. [1] developed a promising radiographic scoring system, with baseline scores being predictive of sputum smear conversion at 2 months, but it is reliant on skilled readers and has not been systematically validated in predominantly HIV-infected study populations with varying CD4 counts. Superior to conventional chest radiography, high-resolution computed tomography (HRCT) is a highly sensitive tool to track endobronchial TB disease extent [2].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Riou, C., du Bruyn, E., Kim, G. H. J., da Costa, I., Lee, J., Sher, A., Wilkinson, R. J., Allwood, B. W., Goldin, J. Tags: Respiratory infections and tuberculosis Research Letters Source Type: research
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