Dosimetry in Lu-177-DOTATATE peptide receptor radionuclide therapy: a systematic review

ConclusionAccording to the present dosimetric review,177Lu-DOTATATE PRRT appears to be a safe and reliable treatment option for advanced GEP-NETs. From the dosimetric point of view, kidneys are theoretically the major organs at risk in177Lu-DOTATATE treatment. The optimization of the number of treatment cycles beyond the prescribed limit of four and the maximum administered activity in each cycle must be determined by individual patient dosimetry in order to reduce the risk of organ toxicities whilst maximizing therapeutic efficacy.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research