L-asparaginase from human breast milk Lactobacillus reuteri induces apoptosis using therapeutic targets Caspase-8 and Caspase-9 in breast cancer cell line

CONCLUSIONS: Breast milk L. reuteri L-asparaginase induces apoptosis via Cas8 and Cas9 upregulation in the breast cancer cell line. L. reuteri L-asparaginase treatment may be the hopeful approach for the management of breast cancer. Furthermore, the results may highlight the fact that the presence of L-asparaginase-producing L. reuteri isolates in human breast milk may aid in breast cancer improvement or even prevention.PMID:37638419 | DOI:10.3233/BD-220074

Source: Breast Disease - August 28, 2023 Category: Cancer & Oncology Authors: Zaman Hussein Hassan Ibtesam Ghadban Auda Likaa Hamied Mahdi Source Type: research