A novel drug combination of Tofacitinib and Iguratimod alleviates rheumatoid arthritis and secondary osteoporosis

CONCLUSION: TOF + IGU alleviated the severity of RRA in the CIA + TNF rat model, relieving joint inflammation, reducing bone erosion, and suppressing pyroptosis. The combined application of TOF and IGU may have a superimposed therapeutic effect on RRA and secondary osteoporotic bone remodeling.PMID:37717316 | DOI:10.1016/j.intimp.2023.110913

Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Jie Chen Qincheng Che Yuying Kou Xing Rong Xiaojie Zhang Minqi Li Qiang Shu Source Type: research