Signaling Circuits and the Apical Extracellular Matrix In Aging: Connections Identified in the Nematode < em > Caenorhabditis elegans < /em >

Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00195.2023. Online ahead of print.ABSTRACTNumerous conserved signaling pathways play critical roles in aging, including insulin, TGF-β, Wnt, and autophagy pathways. Some of these pathways also play prominent roles in the formation and maintenance of the extracellular matrix. The nematode Caenorhabditis elegans has been an enduringly productive system for the identification of conserved mechanisms of biological aging. Recent studies in C. elegans highlight the regulatory circuits between conserved signaling pathways and the extracellular matrix, revealing a bidirectional relationship between these factors and providing a platform to address how regulation of and by the extracellular matrix can impact lifespan and organismal health during aging. These discoveries provide new opportunities for clinical advances and novel therapeutic strategies.PMID:37721005 | DOI:10.1152/ajpcell.00195.2023

Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Hannah Reich Cathy Savage-Dunn Source Type: research