Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis

CONCLUSIONS: Abrogation of lactate-mediated cross-talk between cancer cells and TAM results in durable ADT-independent tumor control in PTEN/p53-deficient AVPC, and warrants further investigation in clinical trials.PMID:37721526 | DOI:10.1158/1078-0432.CCR-23-1441

Source: Clinical Prostate Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Kiranj Chaudagar Hanna M Hieromnimon Anne Kelley Brian Labadie Jordan Shafran Srikrishnan Rameshbabu Catherine Drovetsky Kaela Bynoe Ani Solanki Erica Markiewicz Xiaobing Fan Massimo Loda Akash Patnaik Source Type: research