Cobalt oxide-chitosan based nanocomposites: Synthesis, characterization and their potential pharmaceutical applications

Int J Biol Macromol. 2023 Sep 13:126856. doi: 10.1016/j.ijbiomac.2023.126856. Online ahead of print.ABSTRACTThis research aimed to prepare, characterize, and investigate the biological efficacy of chitosan‑cobalt (II) oxide hybrid nanocomposites against a variety of micrograms. Analytical methods, FTIR, SEM, XRD, and EDX, were utilized to thoroughly characterize the produced CS-CoO nanocomposite. In FTIR spectra, the presence of the chitosan peaks in addition to that of CoO at 681 and 558 cm-1 confirmed that CoO molecules interact with the chitosan backbone. Moreover, in the XRD measurements, significantly less chitosan crystallinity was observed. Due to the incorporation of a larger amount of cobalt oxide within the polymer matrix. Applying the Debye-Sherrer calculation, the crystallite size was obviously reduced from 48.24 nm (5 % wt.) to 19.27 nm (20 % wt.) for the obtained nanocomposites. Furthermore, SEM measurements showed a transformation in the chitosan surface with the physical adsorption of CoO molecules on the surface active sites of chitosan that were visible in SEM graphs. Additionally, EDX determined the amount of Co element within the chitosan, with the sample of 20 % weight being found to be 19.26 % weight. The variable dose well-diffusion method was utilized to assess the efficacy of the CS-Co nanocomposite against a wide range of bacteria and fungi. CS - CoO nanocomposite is more effective than chitosan alone as an antibacterial agent against both Gram-pos...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research