Systematic characterization of a non-transgenic A β1–42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice

ConclusionsIn conclusion, our results provide further evidence on the shifting of LTP/LTD threshold due to a singleicv. Aβ1 –42 injection, which underly cognitive deficits in the early stages of AD. These long-lasting cognitive and functional alterations in males and females validate this model for the study of early amyloidosis in both sexes, thus offering a solid alternative to the inconsistence of amyloidosis transgenic mice models.
Source: Biology of Sex Differences - Category: Biology Source Type: research