Physiological and Regenerative Functions of Sterile Alpha Motif Protein-14 in Hematopoiesis

Samd14 promotes signal pathway duration and intensity in hematopoietic stem/progenitor cells (HSPC) and erythroid progenitors downstream of stem cell factor (SCF) and erythropoietin (Epo) stimulation during regenerative erythropoiesis (1,2). Samd14 shares homology with neurabin proteins (PPP1R9A and PPP1R9B) which promote cell signaling and survival in neurons (3). Neurabin mechanisms-of-action include signaling complex recruitment to actin filaments and controlling specificity of signaling pathway activation within certain cell subtypes (4,5).

Source: Experimental Hematology - September 16, 2023 Category: Hematology Authors: Meg A. Schaefer, Pooja Roy, Srinivas Chava, Ainsley Meyerson, Andrew L. Duncan, Linda Chee, Kyle J. Hewitt Tags: Article Source Type: research