Impact of glycogen synthase kinase-3 ß inhibition on rats' temporomandibular joint collagen-induced rheumatoid arthritis with correlation to miRNA-155/miRNA-24 expression

CONCLUSIONS: Our results reveal for the first-time correlation of miRNA-155 and miRNA-24 that might be implicated in the onset of TMJ RA. Consequently, the treatment of CIA with GSK inhibitor (TDZD-8) yields encouraging results. We predicted the TDZD-8 might protect against CIA by suppressing miRNA-155, miRNA-24, and S100A4 protein levels.PMID:37667918 | DOI:10.26355/eurrev_202308_33393

Source: European Review for Medical and Pharmacological Sciences - September 5, 2023 Category: Drugs & Pharmacology Authors: R H Al-Serwi G Othman A F Dawood A K Alhumaidan H S Alharbi M El-Sherbiny M E Almadani D M A Elsherbini Source Type: research