Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males

ConclusionsOur study delineated the difference in TME between male and female patients with RCC, and demonstrated that the androgen –androgen receptor axis plays an important role in immunosuppression in male RCC. Our findings suggest that androgen receptor inhibitors in combination with immunotherapy may be a promising treatment option for male RCC patients.
Source: Biology of Sex Differences - Category: Biology Source Type: research