Comprehensive genomic analysis of puerarin in inhibiting bladder urothelial carcinoma cell proliferation and migration

CONCLUSION: Our findings support the potential antitumor activity of puerarin in BUC. To the best of our knowledge, bioinformatics investigation suggests that puerarin demonstrates anticancer mechanisms via the upregulation of ITGA1, LAMA3 and 4, LAMB3, PAK2, DMD, and UTRN, all of which are involved in the proliferation and migration of bladder urothelial cancer cells.PMID:37694778 | DOI:10.2174/1574892819666230908110107

Source: Recent Patents on Anti-Cancer Drug Discovery - September 11, 2023 Category: Cancer & Oncology Authors: Yu-Yang Ma Ge-Jin Zhang Peng-Fei Liu Ying Liu Ji-Cun Ding Hao Xu Lin Hao Deng Pan Hai-Luo Wang Jing-Kai Wang Peng Xu Zhen-Duo Shi Kun Pang Source Type: research