Halogenated bisphenol A derivatives potently inhibit human, rat, and mouse gonadal 3 β-hydroxysteroid dehydrogenases: structure-activity relationship and in silico molecular docking analysis

In conclusion, halogenated BPA derivatives are more potent inhibitors of three 3β-HSDs than BPA and there is structure-dependent inhibition. SYNOPSIS: Chlorinated bisphenol derivatives after water chlorination process and other halogenated bisphenols effectively inhibit human and rat 3β-HSD activity, thereby leading to steroid hormone deficiency.PMID:37683804 | DOI:10.1016/j.toxlet.2023.09.002

Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Yang Yu Mengyun Wang Ya Chen Chengshuang Pan Qianjin Fei Yang Zhu Huitao Li Ren-Shan Ge Source Type: research