Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice

Conclusion
Our results highlight that dysfunctional hepatic pIgR enhances alcohol-associated liver disease due to impaired antimicrobial defence by IgA in the gut.

Source: Gut - September 13, 2023 Category: Gastroenterology Authors: Hendrikx, T., Lang, S., Rajcic, D., Wang, Y., McArdle, S., Kim, K., Mikulski, Z., Schnabl, B. Tags: Gut Hepatology Source Type: research