Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen-glucose deprivation condition

CONCLUSIONS: Together, this study revealed the protection of VPA in ex vivo OGD-induced pathological form of neuroplasticity and in vivo PTI-induced brain damage and motor dysfunction through rescuing GABAergic deficiency and the pathological hallmarks of ischemia.PMID:37695500 | DOI:10.1007/s43440-023-00525-w

Source: Pharmacological Reports - September 11, 2023 Category: Drugs & Pharmacology Authors: Ming-Chia Chu Wei-Chang Mao Han-Fang Wu Yun-Chi Chang Ting-I Lu Chi-Wei Lee Yueh-Jung Chung Tsung-Han Hsieh Hsun-Shuo Chang Yih-Fung Chen Chia-Hsien Lin Chih-Wei Tang Hui-Ching Lin Source Type: research