Novel antibiotic susceptibility of an RNA polymerase α-subunit mutant in Pseudomonas aeruginosa

ConclusionsThe discovery of antibiotic susceptibility in an RpoA mutant implicates a new therapeutic approach for treating clinical isolates ofP. aeruginosa with RpoA mutations, using specific antibiotics regulated by MexEF-OprN. More generally, our work suggests that RpoA could serve as a promising candidate target for anti-pathogen therapeutic purposes.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research