Making the case for precision dosing: visualizing the variability of cefepime exposures in critically ill adults

ConclusionCreatinine clearance estimates alone are inadequate for predicting cefepime exposures. Wide variations in cefepime exposure exist among ICU patients, even for those with similar kidney function estimates. Current population adjustment schemes based solely on creatinine clearance will result in unintended high and low exposures leading to safety and efficacy concerns, respectively.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research