The Cardiorenal Effects of Chronic Phosphodiesterase-V Inhibition in Preclinical Diastolic Dysfunction (Stage B Heart Failure)

To determine whether chronic phosphodiesterase-V (PDEV) inhibition with tadalafil will improve urinary sodium excretion, glomerular filtration rate (GFR), plasma cyclic guanosine 3 ’, 5’-monophosphate (cGMP), and urinary cGMP excretion in response to volume expansion (VE) in patients with preclinical diastolic dysfunction (PDD) or stage B heart failure.

Source: Journal of Cardiac Failure - June 6, 2023 Category: Cardiology Authors: SHRAVYA VINNAKOTA, FADI W. ADEL, PAUL M. MCKIE, CHRISTOPHER G. SCOTT, HORNG H. CHEN Tags: Brief Report Source Type: research