An adapted clinical global Impression of improvement for use in Angelman syndrome: Validation analyses utilizing data from the NEPTUNE study

CONCLUSIONS: Our validation analysis of the CGI-I-AS demonstrates its usefulness along with possible areas of improvement. The CGI-I-AS is a potential tool for use in other trials of AS drug candidates, and the process for its development can serve as a road map for the development of assessment tools for other neuropsychiatric disorders with similar complexities and heterogeneity.PMID:37688937 | DOI:10.1016/j.ejpn.2023.08.003

Source: European Journal of Paediatric Neurology - September 9, 2023 Category: Neurology Authors: Pamela Ventola Judith Jaeger Christopher J Keary Alexander Kolevzon Maxwell Adams Bina Keshavan Celia Zinger-Salmun Cesar Ochoa-Lubinoff Source Type: research