TIMP1 shapes an immunosuppressive microenvironment by regulating anoikis to promote the progression of clear cell renal cell carcinoma

CONCLUSIONS: ARGs played crucial roles in tumorigenesis and progression and were positively associated with a poor prognosis. AI had great accuracy in predicting the prognosis and immune characteristics of ccRCC patients. TIMP1 was significantly associated with clinicopathological variables and the immunosuppressive microenvironment, which could be exploited to design novel immunotherapies for ccRCC patients.PMID:37688768 | DOI:10.18632/aging.205005

Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Qiang Li Kai Wei Xi Zhang Yang Lv Miao Li Chenchao Zhou Shifeng Su Daorong Hou Jianquan Hou Source Type: research