SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation

CONCLUSION: Our findings revealed novel role of SENP5 in HR mediated DNA damage repair and cancer resistance, which could be applied as potent prognostic marker and intervention target for cancer radiotherapy.PMID:37684630 | DOI:10.1186/s13046-023-02789-9

Source: Clinical Colorectal Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Tingting Liu Hang Wang Yuanyuan Chen Zhijie Wan Zhipeng Du Hui Shen Yue Yu Shengzhe Ma Ying Xu Zhuqing Li Nanxi Yu Fangxiao Zhang Kun Cao Jianming Cai Wei Zhang Fu Gao Yanyong Yang Source Type: research