Loss of cyclophilin D prolyl isomerase activity desensitizes mitochondrial permeability transition pore opening in isolated cardiac mitochondria, but does not protect in myocardial ischemia-reperfusion injury

Cyclophilin D (CyPD) is the sole member of the cyclophilin (CyP) family of peptidyl prolyl cis-trans isomerases that resides in mitochondria. Although it is generally accepted that CyPD sensitizes opening of the mitochondrial permeability transition pore (PTP) to trigger necrotic cell death, the mechanism remains poorly understood [1,2]. Furthermore, the role of the prolyl isomerase activity of CyPD in mediating these effects remains unresolved.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research