Hypomethylation of DRD2 promotes breast cancer through the FLNA-ERK pathway

The treatment of breast cancer is still challenging [1]. Some tumor cells have a strong ability for self-renewal and produce heterogeneous cells as stem cells [2], which were defined as cancer stem cells (CSCs) by some scholars [3]. Although controversy about their surface markers for isolation and identification remains, these CSC-like cells were tumor cells with highly malignant tumors. Experimental evidence shows that traditional chemotherapy drugs are ineffective on these highly malignant human cancer cells [4].

Source: Cancer Genetics and Cytogenetics - September 9, 2023 Category: Genetics & Stem Cells Authors: Shuoyi Zhang, Ming Zhong, Hongbo Zhu, Qinghua You, Hao Yuan, Yongping Li Tags: Original Article Source Type: research