The Critical Function of microRNAs in Developing Resistance against 5-Fluorouracil in Cancer Cells

Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825144150. Online ahead of print.ABSTRACTAlthough there have been significant advancements in cancer treatment, resistance and recurrence in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into RNA and DNA. Despite its huge benefits in cancer therapy, the application of 5-FU in the clinic is restricted due to the occurrence of drug resistance. MicroRNAs (miRNAs) are small, non-coding RNAs that act as negative regulators in many gene expression processes. Research has shown that changes in miRNA play a role in cancer progression and drug resistance. This review examines the role of miRNAs in 5-FU drug resistance in cancers.PMID:37642002 | DOI:10.2174/1389557523666230825144150
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Source Type: research