A Brain-Lymphatic Connection

Existing dogma in neuroscience states that the brain does not possess the classical lymphatic drainage system found in other parts of body. However, a recent letter in the journal Nature reports the discovery of lymphatic vessels lining the dural sinuses in mice. These were shown to drain immune cells and cerebrospinal fluid (CSF) into the deep cervical lymph nodes. Although more work is yet to be done in humans, this discovery will cause neuroscientists to revisit a number of concepts related to CSF and lymphatic drainage, as well as immune functions in the brain.What can we use from this in teaching undergraduate A&P?When discussing CSF drainage, consider mentioning the possibility that filtration of CSF directly into dural sinuses may be augmented by the newly discovered lymphatic drainage.If you discuss the dogma of the "immune privilege" of the brain, consider mentioning this possible challenge to the concept.If you discuss disorders involving altered immunity, such as multiple sclerosis, consider mentioning this discovery.Bringing up this new information may be useful in discussions related to the process of science—how existing dogmas are sometimes challenged by new information, for example. Perhaps a discussion of the need for more investigation would stimulate students to think about what future steps can be taken to map out a possible lymphatic network in the brain.Want to know more?Brain Drain | The brain contains lymphatic vessels similar to those found else...

Source: The A and P Professor - June 3, 2015 Category: Physiology Authors: Kevin Patton Source Type: blogs