LHPP in glutamatergic neurons of the ventral hippocampus mediates depression-like behavior by dephosphorylating CaMKII α and ERK

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) was recently shown to be a risk gene for major depressive disorder (MDD). LHPP has been proven to dephosphorylate the residues of histidine, serine, threonine, and tyrosine. However, much remains unknown regarding how LHPP contributes to depression.

Source: Biological Psychiatry - September 5, 2023 Category: Psychiatry Authors: Lvping Zhuang, Weijie Gao, Yanbing Chen, Wenting Fang, Hsuan Lo, Xiaoman Dai, Jie Zhang, Wanjing Chen, Qinyong Ye, Xiaochun Chen, Jing Zhang Tags: Priority Communication Source Type: research