Accounting for fractionation and heterogeneous dose distributions in the modelling of osteoradionecrosis in oropharyngeal carcinoma treatment

The majority of patients with oropharyngeal squamous cell carcinoma (OPSCC) are treated with radiotherapy (RT) with or without systemic therapy. A serious late complication is osteoradionecrosis (ORN) of the jaws, which develops most often in the mandible. ORN may cause serious morbidity such as pain, deformity, and even pathologic fractures that need extensive reconstructions [1 –3]. The incidence of ORN in the Intensity Modulated Radiation Therapy (IMRT) era varies considerably between 2% and 12% [4–8].

Source: Radiotherapy and Oncology - August 31, 2023 Category: Radiology Authors: Gerda M. Verduijn, Nienke D. Sijtsema, Yvette van Norden, Wilma D. Heemsbergen, Hetty Mast, Aniel Sewnaik, Denzel Chin, Sarah Baker, Marta E. Capala, Aad van der Lugt, Esther van Meerten, Mischa S. Hoogeman, Steven F. Petit Tags: Original Article Source Type: research