Progress in Hemostasis (Part 1): Improved Management of Inherited Platelet Disorders: Reality or Illusion?

Hamostaseologie. 2023 Aug;43(4):238-240. doi: 10.1055/a-2031-7790. Epub 2023 Aug 23.ABSTRACTPlatelets are key drivers of hemostasis. Low platelet counts, dysfunction in platelet adhesion, and aggregation lead to increased bleeding tendency. Inherited platelet disorders (IPDs) form a highly heterogeneous group of rare diseases with variable bleeding tendency. IPDs may be associated with other signs and symptoms often referred to as "syndromic." The underlying genetic defect may prone patients to develop hematopoietic diseases such as leukemia. Over the last decade, accumulating knowledge in genetics has led to the detection of many "new" platelet disorders. However, still many patients with a well-described platelet dysfunction remain undetected until severe bleeding occurs.PMID:37611603 | DOI:10.1055/a-2031-7790
Source: Hamostaseologie - Category: Hematology Authors: Source Type: research