The translational potential of cholesterol-based therapies for neurological disease

Nature Reviews Neurology, Published online: 29 August 2023; doi:10.1038/s41582-023-00864-5Cholesterol has diverse roles in the brain, and precise regulation of cholesterol production and catabolism is essential for healthy brain function. This Review summarizes cholesterol regulation and function in the brain and discusses evidence of cholesterol dyshomeostasis in age-related neuropathology and a number of neurological diseases. In particular, the authors focus on Huntington disease and insights from rodent models.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research