Bromodomain protein 4 mediates the roles of TGF β1-induced Stat3 signaling in mouse liver fibrogenesis

In conclusion, a network consisting of Stat3 signaling, Smad3 signaling, Egr1, and BrD4 was involved in the effects of TGFβ1 on liver fibrosis, providing new toxicological mechanisms for TGFβ1 in liver fibrogenesis.PMID:37634812 | DOI:10.1016/j.toxlet.2023.08.009

Source: Toxicology Letters - August 27, 2023 Category: Toxicology Authors: Feifan Xu Sidan Lu Xin Jia Yajun Zhou Source Type: research