Exome sequencing findings in children with annular pancreas
ConclusionIQGAP1 andNRCAM are crucial in cell polarization and migration. Mutations result in decreased motility which could possibly cause the ventral bud to not migrate normally. To our knowledge, this is the first study reporting a possible association forIQGAP1 andNRCAM with AP. Our findings of rare genetic variants involved in cell migration in 15% of our population raise the possibility that AP may be related to abnormal cell migration.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Georgia Pitsava,
Nathan Pankratz,
John Lane,
Wei Yang,
Shannon Rigler,
Gary M. Shaw,
James L. Mills Tags: ORIGINAL ARTICLE Source Type: research