Isoliquiritin Ameliorates Ulcerative Colitis in Rats through Caspase 3/HMGB1/TLR4 Dependent Signaling Pathway

CONCLUSION: Isoliquiritin could reduce intestinal inflammation and mucosal damage of TNBS-induced colitis in rats with a certain anti-UC effect. Meanwhile, isoliquiritin treatment also inhibited the expression of HMGB1, TLR4, and MyD88 in LPS-induced Caco-2 cells. These results indicated that isoliquiritin could ameliorate UC through the caspase-3/HMGB1/TLR4-dependent signaling pathway.PMID:37526181 | DOI:10.2174/1566523223666230731115236

Source: Current Gene Therapy - August 1, 2023 Category: Genetics & Stem Cells Authors: Zhiwei Miao Mingjia Gu Faisal Raza Hajra Zafar Jianyi Huang Yuhang Yang Muhammad Sulaiman Jing Yan Yi Xu Source Type: research