Genetic and Metabolic Determinants of Lipoprotein(a)

Lipoprotein(a) [Lp(a)] levels are a well-known independent risk factor for atherosclerotic cardiovascular disease. 70-90% of the variation in Lp(a) levels is genetically determined by the apolipoprotein(a) gene (LPA) locus, but relatively little is known about other regulators. Lp(a) levels and subsequent risk of CVD are associated with SNPs near other genes such as APOE and LDLR but there are currently few FDA approved treatments for elevated Lp(a) beyond PCSK9 inhibitors and plasmapheresis.

Source: Journal of Clinical Lipidology - July 1, 2023 Category: Lipidology Authors: Sarah L Stewart, Oleksandr Savenkov, Maurice A Hurd, Amanda Halstrom, John Falcone, Katerine Claudio, Jyothi Manohar, Fana Dealla, Sonal Kumar, Jessica M Pe ña, Michele Yeung, Judy Tung, Greg Dakin, Esther Wei, Lisa C Hudgins, Laura C Alonso, Shuibing Ch Tags: Clinical Application of Biomarkers Source Type: research