Lymphatic endothelial transcription factor Tbx1 promotes an immunosuppressive microenvironment to facilitate post-myocardial infarction repair

Myocardial infarction (MI)-induced autoimmunity is detrimental, but it is usually resolved after the heart heals. However, the mechanism is unclear. Wang et  al. report that Tbx1 upregulation in lymphatic endothelial cells enforces an immunosuppressive microenvironment to inhibit autoreactive CD8+ T cell expansion and increase reparative macrophages to repair post-MI damage.

Source: Immunity - August 24, 2023 Category: Allergy & Immunology Authors: Wenfeng Wang, Xiao Li, Xiaoning Ding, Shanshan Xiong, Zhenlei Hu, Xuan Lu, Kan Zhang, Heng Zhang, Qianwen Hu, Kaa Seng Lai, Zhongxiang Chen, Junjie Yang, Hejie Song, Ye Wang, Lu Wei, Zeyang Xia, Bin Zhou, Yulong He, Jun Pu, Xiao Liu, Rongqin Ke, Tao Wu, C Tags: Article Source Type: research