Development of cobalt (Co) ‐doped monetites for bone regeneration

AbstractCobalt-doped monetite powders were synthesized by coprecipitation method under a cobalt nominal content between 2 and 20  mol % of total cation. Structural characterization of samples was performed by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy. XRD results indicated that the Co-doped samples exhibited a monetite singl e-phase with the cell parameters and crystallite size dependent on the amount of substitutional element incorporated into the triclinic crystalline structure. Cell viability and adhesion assays using pre-osteoblastic cells showed there is no toxicity and the RTqPCR analysis showed significant differ ences in the expression for osteoblastic phenotype genes, showing a potential material for the bone regeneration.

Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - August 23, 2023 Category: Materials Science Authors: Gerson Santos Almeida, Marcel Rodrigues Ferreira, C élio Junior Costa Fernandes, Luísa Camilo Suter, Maria Gabriela Jacheto Carra, Diego Rafael Nespeque Correa, Elidiane Cipriano Rangel, Margarida Juri Saeki, Willian Fernando Zambuzzi Tags: RESEARCH ARTICLE Source Type: research