Myeloid Hif2 α is not essential to maintain systemic iron homeostasis

Systemic iron homeostasis is tightly regulated as both excess and deficiency of iron have deleterious effects. Despite tight systemic regulation, more than one billion people worldwide suffer from iron-related disorders [1,2]. Systemic iron homeostasis requires heterotissue communication. Diet is the sole source of iron, and it is actively absorbed in the small intestine through the transporter divalent metal transporter-1 (Dmt1; gene name Slc11a2) [3,4]. Iron is stored within enterocyte in an iron storage protein, ferritin (FTN) or exported out of the cell and into the circulation through the only known mammalian iron exporter ferroportin (Fpn; gene name Slc40a1) [5,6].

Source: Experimental Hematology - August 8, 2023 Category: Hematology Authors: Chesta Jain, Sanjana Parmini, Wesley Huang, Sean Hannifin, Rashi Singhal, Nupur K. Das, Kyoung Eun Lee, Yatrik M. Shah Tags: Article Source Type: research