Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice

Hyperactivation of JAK2 kinase is a common feature among human Ph- myeloproliferative neoplasms (MPNs),1 and has also been hypothesized as a defining feature of leukemic stem cells in acute myeloid leukemia (AML).2 Myeloid neoplasms have been found to harbor dysregulation of multiple intracellular signaling pathways, among which one of the most widespread is the NF κB signaling pathway. NFκB pathway hyperactivation has been identified in AML, myelodysplastic syndromes (MDS), chronic myeloid leukemia (CML), and MPNs.

Source: Experimental Hematology - August 20, 2023 Category: Hematology Authors: Daniel A.C. Fisher, Angelo B.A. Laranjeira, Tim Kong, Steven C. Snyder, Kevin Shim, Mary C. Fulbright, Stephen T. Oh Tags: Article Source Type: research