Inflammatory damage on respiratory and nervous systems due to hRSV infection.

Inflammatory damage on respiratory and nervous systems due to hRSV infection.
Curr Opin Immunol. 2015 May 27;36:14-21
Authors: Bohmwald K, Espinoza JA, Becerra D, Rivera K, Lay MK, Bueno SM, Riedel CA, Kalergis AM
Abstract
The exacerbated inflammatory response elicited by human Respiratory Syncytial Virus (hRSV) in the lungs of infected patients causes a major health burden in the pediatric and elderly population. Since the discovery of hRSV, the exacerbated host immune-inflammatory response triggered by this virus has been extensively studied. In this article, we review the effects on the airways caused by immune cells and cytokines/chemokines secreted during hRSV infection. While molecules such as interferons contribute at controlling viral infection, IL-17 and others produce damage to the hRSV-infected lung. In addition to affecting the airways, hRSV infection can cause significant neurologic abnormalities in the host, such as seizures and encephalopathy. Although the origin of these symptoms remains unclear, studies from patients suffering neurological alteration suggest an involvement of the inflammatory response against hRSV.
PMID: 26026788 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - May 27, 2015 Category: Allergy & Immunology Authors: Bohmwald K, Espinoza JA, Becerra D, Rivera K, Lay MK, Bueno SM, Riedel CA, Kalergis AM Tags: Curr Opin Immunol Source Type: research