Epileptogenic Tubers Are Associated with Increased Kurtosis of Susceptibility Values: A Combined Quantitative Susceptibility Mapping and Stereoelectroencephalography Pilot Study [FUNCTIONAL]

CONCLUSIONS:
Our finding of increased kurtosis of quantitative susceptibility mapping values (heavy-tailed distribution) was highly specific, suggesting that it may be a useful biomarker to identify putative epileptogenic tubers in tuberous sclerosis complex. This finding motivates the investigation of underlying tuber mineralization and other properties driving kurtosis changes in quantitative susceptibility mapping values.

Source: American Journal of Neuroradiology - August 9, 2023 Category: Radiology Authors: Chari, A., Sedlacik, J., Seunarine, K., Piper, R. J., Hales, P., Shmueli, K., Mankad, K., Löbel, U., Eltze, C., Moeller, F., Scott, R. C., Tisdall, M. M., Cross, J. H., Carmichael, D. W. Tags: FUNCTIONAL Source Type: research