Cellular polyploidy in organ homeostasis and regeneration

Protein Cell. 2023 Aug 1;14(8):560-578. doi: 10.1093/procel/pwac064.ABSTRACTPolyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.PMID:37526344 | PMC:PMC10392032 | DOI:10.1093/procel/pwac064
Source: Protein and Cell - Category: Cytology Authors: Source Type: research