Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles

Monoacylglycerol (or monoglyceride) lipase (MAGL, MGL) is a serine hydrolase that degrades monoglycerides including the endocannabinoid 2-arachidonoyl glycerol (2-AG) [1]. It is, therefore, part of the endocannabinoid system (ECS), a network of molecules that includes endocannabinoids (e.g. 2-AG), cannabinoid (e.g. CB1 and CB2) receptors, and enzymes for synthesis and degradation of endocannabinoids, maintaining homeostasis in many tissues [2]. In the brain, MGL generates arachidonic acid as precursor for the generation of neuroinflammatory prostaglandins [3].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 8, 2023 Category: Biomedical Science Authors: Eva Gruden, Melanie Kienzl, Carina Hasenoehrl, Arailym Sarsembayeva, Dusica Ristic, Sophie Theresa Schmid, Kathrin Maitz, Ulrike Taschler, Lisa Hahnefeld, Robert Gurke, Dominique Thomas, Julia Kargl, Rudolf Schicho Source Type: research