Neurodegenerative disorders: New Huntington disease target identified

Nature Reviews Drug Discovery 14, 386 (2015). doi:10.1038/nrd4652 Author: Sarah Crunkhorn Huntington disease (HD) is caused by the expansion of a CAG repeat tract in the gene encoding huntingtin (HTT), resulting in aggregation of a toxic mutant HTT protein (mHTT). Using an siRNA-based screen in human cultured cells, followed by hit validation in Drosophila melanogaster,
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research