Variability of longitudinal triglyceride phenotype in patients heterozygous for pathogenic APOA5 variants

Hypertriglyceridemia (HTG) – i.e. elevated fasting plasma triglyceride (TG) concentration – is a common and complex dyslipidemia.1,2 HTG is typically categorized as either mild-to-moderate (2 to 9.9 mmol/L or 175 to 875 mg/dL) or severe (>10 mmol/L or>875 mg/dL), which have a North American prevalence of about one in four and one in 400, respectively.2 HTG is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD), while severe HTG is associated with increased risk of acute pancreatitis, which is potentially life-threatening1.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Tags: Original Research Source Type: research