Neuroactive changes in the bowel of patients with IBS on low FODMAP diet: another piece of the puzzle

The publication of Rome IV saw the introduction of the term ‘disorder of gut brain interaction’ as a replacement for the previously used terminology ‘functional gastrointestinal (GI) disorder’ to describe GI conditions classified by symptoms related to any combination of motility disturbance, visceral hypersensitivity, dysregulated mucosal or immune function and gut microbiota, or altered central nervous system processing. A driving force for this change was a need to address the false perception that ‘functional’ disorders such as irritable bowel syndrome (IBS) are less real than ‘organic’ disorders such as inflammatory bowel disease (IBD) due to the absence of frank pathology in functional disorders which were often considered psychiatric or undefined in nature. While there is no doubt tissue from patients with IBS do not display histological or transcriptomic changes to the extent seen in IBD patients an ever-growing body of data has repeatedly shown marked functional effects of samples...
Source: Gut - Category: Gastroenterology Authors: Tags: Gut Commentary Source Type: research