Vitamin D May Play a Vital Role in Alleviating Type 2 Diabetes Mellitus by Modulating the Ferroptosis Signaling Pathway
Horm Metab Res DOI: 10.1055/a-2122-5701Ferroptosis is an iron-dependent death mode mediated by the aggregation of lipid
peroxides and lipid-reactive oxygen species. It is characterized by
iron-dependent lipid peroxide accumulation accompanied by oxidoreductase
deficiency. Pancreatic beta cell dysfunction and insulin resistance are two
major causes of type 2 diabetes mellitus (T2DM). Iron accumulation and
metabolism may play a role in the development of T2DM. The molecular mechanism
of β cell apoptosis and iron death in T2DM were reviewed. In addition,
we discuss recent insights on the relationship between the trace element iron
and apoptosis of β cells in T2DM. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Zhang, Qiong-Wen Wang, Yan Tong, Zi-Ying Li, Cui-Ping He, Lian-Ping Tags: Mini-Review Source Type: research
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