Metformin-Induced Receptor Turnover Alters Antibody Accumulation in HER-Expressing Tumors

Conclusion: The findings that metformin decreases cell-surface HER receptors and reduces antibody–tumor binding may have significant implications for the use of antibodies targeting these receptors in cancer treatment and molecular imaging.

Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Panikar, S. S., Keltee, N., Berry, N.-K., Shmuel, S., Fisher, Z. T., Brown, E., Zidel, A., Mabry, A., Pereira, P. M. R. Tags: FEATURED BASIC SCIENCE ARTICLE Source Type: research