Cancers, Vol. 15, Pages 3863: Effect of a Multi-Ingredient Coriolus-versicolor-Based Vaginal Gel in Women with HPV & ndash;Dependent Cervical Lesions: The Papilobs Real-Life Prospective Study
The objective was to prospectively evaluate the results of using a Coriolus-versicolor-based vaginal gel (Papilocare®) on HPV-dependent low-grade cervical lesion repair in a real-life scenario. HPV-positive women ≥ 25 years with ASCUS/LSIL cervical cytology results and concordant colposcopy images were included, receiving the vaginal gel one cannula/day for 21 days (first month) + one cannula/alternate days (five months). A 6-month second treatment cycle was prescribed when needed. Repair of the cervical low-grade lesions through cytology and colposcopy, HPV clearance, and level of satisfaction, and tolerability were evaluated. In total, 192 and 201 patients accounted for the total and safety analyses, respectively, and 77.1% repaired cervical lesions at 6 or 12 months (76.0% for high-risk HPV). Additionally, 71.6% achieved HPV clearance throughout the study’s duration (70.6% for high-risk HPV). Satisfaction level was rated 7.9 and 7.5 out of 10 at 6 and 12 months, respectively. Only three mild–moderate product-related adverse events were reported, and all of them were resolved by the end of the study. In our study, we observed higher regression rates of low-grade cervical lesions in women treated with Papilocare® vaginal gel than spontaneous regression rates reported in the literature.
Source: Cancers - Category: Cancer & Oncology Authors: Javier Cort és Bordoy Javier de Santiago Garc ía Marta Agenjo Gonz ález Dami án Dexeus Carter Gabriel Fiol Ruiz Carmen Garc ía Ferreiro Silvia P. Gonz ález Rodríguez Marta Gurrea Soteras Ester Mart ínez Lamela Santiago Palacios Gil-Antu ñano Jos Tags: Article Source Type: research
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