Effects of polymorphisms in pregnane X receptor and ABC transporters on afatinib in Japanese patients with non-small cell lung cancer: pharmacogenomic –pharmacokinetic and exposure–response analysis

ConclusionsTheNR1I2 7635A allele was related to a lower afatinib CL/F. Based on the AUC of 689  ng h/mL and CL/F, the optimal doses for patients with theNR1I2 7635G/G genotype and 7635A allele were recommended to be set at 40 and 30  mg/day, respectively, and subsequent adjustment of the maintenance dose based on the plasma concentrations of afatinib may be necessary to avoid afatinib-related adverse events.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research