Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells

CONCLUSION: ISL induced ferroptosis in GBC mainly by activating p62-Keap1-Nrf2-HMOX1 signaling pathway and down-regulating GPX4 in vitro and in vivo. This evidence may provide a new direction for the treatment of GBC.PMID:37488674 | DOI:10.1097/CM9.0000000000002675

Source: Chinese Medical Journal - July 24, 2023 Category: General Medicine Authors: Zeyu Wang Weijian Li Xue Wang Qin Zhu Liguo Liu Shimei Qiu Lu Zou Ke Liu Guoqiang Li Huijie Miao Yang Yang Chengkai Jiang Yong Liu Rong Shao Xu'an Wang Yingbin Liu Source Type: research