Radiographic grading system for usual interstitial pneumonitis correlates with mortality and may serve as a surrogate endpoint in clinical trials

Usual interstitial pneumonia (UIP)/ idiopathic pulmonary fibrosis (IFP) is a relentlessly progressive lung disease with outcomes similar to cancer. We have previously established a radiologic grading system for UIP and demonstrated that it correlates with pulmonary function tests; here we test the hypothesis that it correlates with mortality. Validating a correlation with mortality will demonstrate the utility of this system for monitoring progression over time clinically and in trials of anti-fibrotic agents.
Source: Clinical Imaging - Category: Radiology Authors: Tags: Cardiothoracic imaging Source Type: research